Contra-indicated in patients with active pathological bleeding or with a mechanical prosthetic heart valve.
- TRADE NAME: Pradaxa (Boehringer Ingelheim)
- INDICATIONS: Prevention of venous thromboembolic events, reduce stroke risk
- CLASS: Anticoagulant (antithrombotic), Thrombin inhibitor
- HALF-LIFE: 2.5 days
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Amiodarone, Antacids, Anticoagulants, Atorvastatin, Carbamazepine, Clarithromycin, Clopidogrel, Collagenase, Cyclosporine, Daclatasvir, Darunavir, Dasatinib, Deferasirox, Desirudin, Dextran, Diclofenac, Dronedarone, Fondaparinux, Heparin, Ibritumomab, Itraconazole, Ketoconazole, Ketorolac, Lapatinib, Meloxicam, Nandrolone, Neratinib, NSAIDs, P-glycoprotein inducers and inhibitors, Pantoprazole, Pentosan, Phenytoin, Polysulfate sodium, Prostacyclin analogues, Proton pump inhibitors, Quinidine, Rifampin, Rivaroxaban, Salicylates, St John's Wort, Sulfinpyrazone, Tacrolimus, Telaprevir, Thrombolytic agents, Ticlopidine, Tipranavir, Tositumomab & Iodine131, Ulipristal, Verapamil, Vitamin K antagonists
- See adverse reactions attributed to class:
DISCONTINUING PRADAXA IN PATIENTS WITHOUT ADEQUATE CONTINUOUS ANTICOAGULATION INCREASES RISK OF STROKE
See full prescribing information for complete boxed warning.
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Page last updated 06/07/2026
