The prolonged use of chlorpromazine can produce a gray-blue or purplish pigmentation over light-exposed areas. This is a result of either dermal deposits of melanin, a chlorpromazine metabolite, or a combination of both. Chlorpromazine melanosis is seen more often in women.
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- TRADE NAMES: Chloractil; Chlorazin; Chlorpromanyl; Esmino; Largactil; Novo-Chlorpromazine; Ormazine; Propaphenin; Prozin; Thorazine (GSK)
- INDICATIONS: Psychosis, manic-depressive disorders
- CLASS: Antiemetic, Antipsychotic, Muscarinic antagonist, Phenothiazine
- HALF-LIFE: initial: 2 hours; terminal: 30 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Alcohol, Antihistamines, Arsenic, Asenapine, Chlorpheniramine, Dofetilide, Epinephrine, Evening Primrose, Guanethidine, Lisdexamfetamine, Mivacurium, Pimavanserin, Propranolol, Quinolones, Sodium Picosulfate, Sparfloxacin, Tetrabenazine, Zolpidem
- See adverse reactions attributed to class:
INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS
See full prescribing information for complete boxed warning.
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Page last updated 08/20/2025
