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- TRADE NAME: Rydapt (Novartis)
- INDICATIONS: Aggressive systemic mastocytosis, systemic mastocytosis with associated hematological neoplasm, or mast cell leukemia; acute myeloid leukemia (FLT3 mutation-positive) in combination with cytarabine and daunorubicin induction and cytarabine consolidation
- CLASS: FLT3 (FMS-like tyrosine kinase 3) inhibitor, Kinase inhibitor, Multikinase inhibitor, Tyrosine kinase inhibitor
- HALF-LIFE: 21 hours
- FDA APPROVAL DATE: 04/28/2017
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Boceprevir, Carbamazepine, Clarithromycin, Cobicistat, Conivaptan, Danoprevir, Diltiazem, Elvitegravir, Enzalutamide, Grapefruit Juice, Idelalisib, Indinavir, Itraconazole, Ketoconazole, Lopinavir, Mitotane, Nefazodone, Nelfinavir, Ombitasvir/Paritaprevir/Ritonavir, Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir, Phenytoin, Posaconazole, Rifampin, Ritonavir, Saquinavir, St John's Wort, Stong CYP3A inducers and inhibitors, Tipranavir, Troleandomycin, Voriconazole - PREGNANCY: May cause fetal toxicity based on findings in animal studies
- See adverse reactions attributed to class:
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Page last updated 05/28/2026
