See also separate entries for sofosbuvir and sofosbuvir & velpatasvir.
- TRADE NAME: Vosevi (Gilead)
- INDICATIONS: Chronic HCV infection
- CLASS: Direct-acting antiviral, Hepatitis C virus NS3/4A protease inhibitor (voxilaprevir), Hepatitis C virus NS5A inhibitor (velpatasvir), Hepatitis C virus nucleotide analog NS5B polymerase inhibitor (sofosbuvir)
- HALF-LIFE: <29 hours (sofosbuvir); 17 hours (velpatasvir); 33 hours (voxilaprevir)
- FDA APPROVAL DATE: 07/18/2017
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Amiodarone, Atazanavir, Carbamazepine, Cyclosporine, Efavirenz, Lopinavir, Oxcarbazepine, Phenobarbital, Phenytoin, Pitavastatin, Rifabutin, Rifampin, Rifapentine, Ritonavir, Rosuvastatin, St John's Wort, Tipranavir - PREGNANCY: Insufficient evidence to inform drug-associated risk
- See adverse reactions attributed to class:
RISK OF HEPATITIS B VIRUS REACTIVATION IN PATIENTS COINFECTED WITH HCV AND HBV
See full prescribing information for complete boxed warning.
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Page last updated 08/20/2025
