Contra-indicated in patients with severe hepatic impairment (Child-Pugh C).
- TRADE NAME: Mavyret (AbbVie)
- INDICATIONS: Chronic HCV genotype 1–6 infection
- CLASS: Direct-acting antiviral, Hepatitis C virus NS3/4A protease inhibitor (glecaprevir), Hepatitis C virus NS5A inhibitor (pibrentasvir)
- HALF-LIFE: 6 hours (glecaprevir); 13 hours (pibrentasvir)
- FDA APPROVAL DATE: 08/03/2017
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Atazanavir, Atorvastatin, Carbamazepine, Cyclosporine, Darunavir, Efavirenz, Lopinavir, Lovastatin, Oral Contraceptives, Rifampin, Ritonavir, Simvastatin, St John's Wort - PREGNANCY: Insufficient evidence to inform drug-associated risk
- See adverse reactions attributed to class:
RISK OF HEPATITIS B VIRUS REACTIVATION IN PATIENTS COINFECTED WITH HCV AND HBV
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Page last updated 08/20/2025
