Hyperuricemia: Elevations in serum uric acid have occurred. Assess uric acid levels periodically as clinically indicated. Monitor for signs and symptoms of hyperuricemia, and initiate treatment with urate-lowering drugs as appropriate.
Bempedoic acid is associated with an increased risk of tendon rupture or injury. Discontinue treatment immediately if a patient experiences rupture of a tendon.
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- TRADE NAMES: ETC-1002; Nexletol (Esperion Therapeutics)
- INDICATIONS: An adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional lowering of LDL-C.
- CLASS: Adenosine triphosphate-citrate lyase inhibitor
- HALF-LIFE: ~21 hours
- FDA APPROVAL DATE: 02/21/2020
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Pravastatin, Simvastatin - PREGNANCY: Discontinue bempedoic acid when pregnancy is recognized unless the benefits of therapy outweigh the potential risks to the fetus. Breastfeeding is not recommended.
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Page last updated 08/20/2025
