Topiramate drug interactions | Litt's Drug Eruption and Reaction Database

Topiramate comment watch save

TRADE NAMES: Qsymia (Vivus); Qudexy (Upsher-Smith); Topamax (Janssen); Trokendi XR (Supernus)
INDICATIONS:
Partial onset seizures; migraine.

Adjunct for the treatment of obesity and for weight loss management in defined populations and health conditions.
CLASS: Anti-obesity / weight loss pharmacotherapy, Anticonvulsant (see also antiepileptic (anti-seizure)), Mood stabilizer, Neuroprotectant
HALF-LIFE: 21 hours

CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Eslicarbazepine, Levonorgestrel, Metformin, Rufinamide, Ulipristal, Valproic Acid

See adverse reactions attributed to class:
Anti-obesity / weight loss pharmacotherapy
Anticonvulsant (see also antiepileptic (anti-seizure))
Mood stabilizer

Qsymia, a combination of phentermine and topiramate, has been approved by the FDA for chronic weight management.

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Page last updated 06/28/2025

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<1% 1‑5% 5‑10% 10‑15% 15‑20% 20‑30% >30%

Hospitalization possible
Life threatening
Fatal

Breast feeding

Geriatric

Pediatric