Edema / fluid retention

• (2016): Ennis H+, Cochrane Database Syst Rev 2, CD002069 [REVIEW]
• (2014): Ennis H+, Cochrane Database Syst Rev 1, CD002069 [REVIEW]

Flushing / rubefaction

• (2016): Ennis H+, Cochrane Database Syst Rev 2, CD002069 [REVIEW]
• (2014): Ennis H+, Cochrane Database Syst Rev 1, CD002069 [REVIEW]

Peripheral edema

• (2017): Rirash F+, Cochrane Database Syst Rev 12, CD000467 [REVIEW]

Rash

• (2022): Wu Y+, Front Cardiovasc Med Sep (e-Collection) (2 cases)

Hirsutism

• (2022): Wu Y+, Front Cardiovasc Med Sep (e-Collection) (5 cases)

Gingival hyperplasia / gingival hypertrophy / gingival enlargement / gingival overgrowth

• (2022): Cseke Á+, Orv Hetil (Hungarian) 163(13), 506-512 (grade 3 / 10 cases)
• (2022): Wu Y+, Front Cardiovasc Med Sep (e-Collection) 41% (accompanied by varying degrees of dental dysplasia)

Atrioventricular block

• (2022): Wu Y+, Front Cardiovasc Med Sep (e-Collection) (7 cases)

Bradycardia / sinus bradycardia

• (2022): Wu Y+, Front Cardiovasc Med Sep (e-Collection) 28%

Hypotension

• (2022): Wu Y+, Front Cardiovasc Med Sep (e-Collection) 31%

Palpitation

• (2017): Rirash F+, Cochrane Database Syst Rev 12, CD000467 [REVIEW]

Headache

• (2017): Rirash F+, Cochrane Database Syst Rev 12, CD000467 [REVIEW]
• (2016): Ennis H+, Cochrane Database Syst Rev 2, CD002069 [REVIEW]
• (2014): Ennis H+, Cochrane Database Syst Rev 1, CD002069 [REVIEW]

Vertigo / dizziness

• (2017): Rirash F+, Cochrane Database Syst Rev 12, CD000467 [REVIEW]

Constipation

• (2022): Wu Y+, Front Cardiovasc Med Sep (e-Collection) (2 cases)

Esophagitis

• (2022): Abdi S+, Gastroenterol Hepatol Bed Bench 15(3), 219-224 [REVIEW]

Nausea

• (2017): Rirash F+, Cochrane Database Syst Rev 12, CD000467 [REVIEW]

Adverse effects / adverse reactions

• (2025): Wang H+, Curr Hypertens Rev Feb, Online ahead of print [REVIEW]

Dental dysplasia

• (2022): Wu Y+, Front Cardiovasc Med Sep (e-Collection) 41% (accompanied by gingival hyperplasia)