Contra-indicated in patients with congestive heart failure or active pathological bleeding.
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- TRADE NAME: Pletal (Otsuka)
- INDICATIONS: Peripheral vascular disease, intermittent claudication
- CLASS: Antiplatelet (antithrombotic), Neuroprotectant, Phosphodiesterase inhibitor, Vasodilator, peripheral
- HALF-LIFE: 11–13 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Anagrelide, Anticoagulants, Antifungals, Antiplatelet agents, Clarithromycin, Collagenase, Conivaptan, CYP2C19 inhibitors, CYP3A4 inducers or inhibitors, Dasatinib, Deferasirox, Diltiazem, Drotrecogin Alfa, Erythromycin, Esomeprazole, Fondaparinux, Glucosamine, Grapefruit Juice, High-fat foods, Ibritumomab, Itraconazole, Ketoconazole, Macrolide antibiotics, NSAIDs, Omeprazole, PEG-Interferon, Pentosan, Pentoxifylline, Prostacyclin analogues, Salicylates, St John's Wort, Telithromycin, Thrombolytic agents, Tositumomab & Iodine131, Voriconazole
- See adverse reactions attributed to class:
CONTRA-INDICATED IN HEART FAILURE PATIENTS
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Page last updated 08/20/2025
