PEG-interferon is commonly administered with ribavirin and many of the reactions listed below are in combination therapy with this drug.
Contra-indicated in patients with known hypersensitivity reactions, such as urticaria, angioedema, bronchoconstriction, anaphylaxis, Stevens-Johnson syndrome, and toxic epidermal necrolysis to interferon alpha or any other product component; or with autoimmune hepatitis.
- TRADE NAMES: Pegasys; PegIntron (Schering); Sylatron (Schering)
- INDICATIONS: Chronic hepatitis C, melanoma
- SYNONYM: Peg-interferon alfa-2a / Peg-interferon alfa-2b
- CLASS: Immunomodulator, Interferon
- HALF-LIFE: ~40 hours
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
ACE inhibitors, Acetaminophen, Aldesleukin, Bupivacaine, Cilostazol, Cinacalcet, CYP2C9 substrates, CYP2D6 substrates, Delavirdine, Duloxetine, Estradiol, Fesoterodine, Fingolimod, Fluoxetine, Indinavir, Melphalan, Methadone, Methylnaltrexone, Pantoprazole, Pegloticase, Ribavirin, Sildenafil, Tapentadol, Telbivudine, Theophylline, Theophylline derivatives, Tiotropium, Trimethoprim, Voriconazole, Warfarin, Zidovudine - PREGNANCY: pregnancy category will be X when used in combination with ribavirin
- See adverse reactions attributed to class:
RISK OF SERIOUS DISORDERS AND RIBAVIRIN-ASSOCIATED EFFECTS and DEPRESSION AND OTHER NEUROPSYCHIATRIC DISORDERS
See full prescribing information for complete boxed warning.
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Page last updated 06/21/2026
