Contra-indicated in patients with dihydropyrimidine dehydrogenase deficiency.
Tolak cream contains peanut oil and should be used with caution in peanut-sensitive individuals.
- TRADE NAMES: 5-fluorouracil (Taj); 5-FU; Carac (Valeant); Efudex (Valeant); Efudix; Efurix; Fluoroplex (Allergan); Fluorouracil Injection, USP (Bioniche); Tolak (Hill Dermac)
- INDICATIONS: Palliative management of malignant neoplasms especially of the gastrointestinal tract, breast, liver and pancreas; topical therapy for actinic keratoses. Advanced pancreatic cancer (in combination with oxaliplatin/irinotecan/leucovorin (FOLFIRINOX or FOLFOXIRI)). Used in combination with leucovorin and irinotecan (FOLFIRI) for treatment of advanced-stage and metastatic colorectal cancer. Used in combination with leucovorin and oxaliplatin (FOLFOX; mFOLFOX6) for treatment of colorectal cancer.
- SYNONYM: 5-FU
- CLASS: Antimetabolite, Antineoplastic / anticancer agent (see also Immune checkpoint inhibitor), Fluoropyrimidine
- HALF-LIFE: 8–20 minutes
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
Aldesleukin, Bromelain, Cimetidine, Granulocyte Colony-Stimulating Factor (G-CSF), Metronidazole, Tegafur/Gimeracil/Oteracil, Tegafur/Gimeracil/Oteracil, Tinidazole
- See adverse reactions attributed to class:
Antineoplastic / anticancer agent (see also Immune checkpoint inhibitor)
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Page last updated 07/14/2026
