Aldactazide is spironolactone and hydrochlorothiazide.
Hydrochlorothiazide is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome.
- TRADE NAMES: Aldactazide (Pfizer); Aldactone (Pfizer); Aldopur; Almatol; Diram; Merabis; Novo-Spiroton; Osiren; Spiroctan; Tensin
- INDICATIONS: Hyperaldosteronism, hirsutism, hypertension, edema for patients with congestive heart failure, cirrhosis of the liver or nephrotic syndrome
- CLASS: Aldosterone antagonist / mineralocorticoid receptor antagonist (MRA), Diuretic
- HALF-LIFE: 78–84 minutes
- CLINICALLY IMPORTANT, POTENTIALLY HAZARDOUS INTERACTIONS WITH:
ACE inhibitors, Alcohol, Amiloride, Barbiturates, Benazepril, Captopril, Cyclosporine, Enalapril, Fosinopril, Lisinopril, Mitotane, Moexipril, Narcotics, NSAIDs, Potassium chloride, Potassium Iodide, Quinapril, Ramipril, Trandolapril, Triamterene, Zofenopril
- See adverse reactions attributed to class:
Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats
See full prescribing information for complete boxed warning.
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Page last updated 08/20/2025
